☀️ Summer launch: the complete NAD+ system, from under £1 a day
⚡ NAD+ Optimisation System · 7 Ingredients
NMN is only step 1. NAD Surge is all 5.
Taken NMN for months and barely felt it? It only feeds one of your three NAD+ pathways. NAD Surge feeds all three, shields them from CD38, and sustains the methylation underneath. The complete system, not step one.
Your NAD+ peaks in your twenties. Then it falls, year after year.
You started paying attention because you could feel it...
The afternoons that slip away from you. Recovery that drags for days. That quiet wish to stay sharp for a long time yet.
So you did the reading. You listened to the podcasts.
And you started supplementing... NMN, NR, one of the dozen options out there.
Then months went by.
...and the energy everyone raves about barely showed up.
The fog would lift for an hour... then roll straight back in.
So you start to wonder.
Maybe you're just one of the people it doesn't work for.
Or maybe... you've quietly burned months, and a few hundred pounds, on the wrong bottle.
Why "more NMN" stops working
As NAD+ falls with age, the enzyme that destroys it (CD38) climbs. Past midlife, you're draining faster than one precursor can build.
NAD+ you haveCD38 (the drain)
~50%
By age 50, your NAD+ can sit at half of your twenties. And CD38 only keeps climbing.
You're not imagining it. The science isn't wrong. The approach is just incomplete.
Most NAD+ supplements get the first part right.
They hand you a precursor. NMN, or NR. One molecule. One pathway. One way in.
Then they stop.
But your body doesn't run on one route... it runs on three.
And even when you flog that one route harder, two things quietly undo you.
First, CD38... the enzyme that tears NAD+ down as fast as you build it.
Then methyl burn... every molecule of NMN you process eats through your methyl groups.
Until "methylation debt" hands you back the exact fog, fatigue and low mood you were trying to fix in the first place.
One precursor. One pathway. No protection. No methylation support. That isn't a system. That's step 1.
Build · Protect · Sustain
The three layers your current supplement is missing.
NAD Surge didn't start in a lab.
It started with a pattern we couldn't unsee...
Scroll any NAD+ forum and the same line shows up, again and again:
"I've taken NMN for months... and I feel nothing."
Thousands of them. Smart, careful people. Buying premium NMN, taking it every day... and quietly giving up.
So we went back to the science with a harder question.
The answer came down to three missing pieces.
01
Layer 1 · Build
Feed all three NAD+ routes
Three precursors. Three separate ways into NAD+ production. Instead of betting everything on one door that may already be jammed shut.
02
Layer 2 · Protect
Stop CD38 draining what you build
Two natural CD38 inhibitors slow the enzyme that tears NAD+ down as fast as you make it. Finally, a full bathtub with the drain plugged.
03
Layer 3 · Sustain
Protect your methylation
A methyl donor and its cofactor replace the methyl groups NMN burns through, heading off the fatigue and fog of methylation debt.
Layer 1Build
Feed all three pathways
Your body makes NAD+ through three separate routes. Most supplements feed just one. Saturate it, and you hit a ceiling no matter how much you take. NAD Surge opens all three at once.
NMN
300mg · direct route
NR
250mg · second route
Niacin
150mg · third route
NAD+ productionthree doors open, not one
NMN300mg
The most direct route into your cells. It's also the one route most supplements stop at.
NR250mg
A completely different cellular route into NAD+, shown to raise NAD+ levels in human trials (Martens et al., 2018, Nature Communications).
Niacin150mg
A third, separate route to NAD+ that most supplements ignore completely.
Layer 2Protect
Stop CD38 draining what you build
CD38 is the main enzyme that breaks NAD+ down inside your cells, and it climbs as you age. The older you get, the faster it tears down the NAD+ you're working to build. Taking NMN without touching CD38 is like filling a bathtub with the drain wide open.
Apigenin's effect on NAD+ in lab studies
By suppressing CD38, apigenin raised NAD+ by roughly 50% (Escande et al., 2013, Diabetes).
baseline
CD38 unchecked
+~50%
with apigenin
Quercetin250mg
A flavonoid that helps slow CD38. It pulls double duty too, softening the mild flush niacin can cause.
Apigenin100mg
Shown in lab studies to raise NAD+ by roughly 50% by suppressing CD38 (Escande et al., 2013, Diabetes).
Layer 3Sustain
Protect your methylation
This is the layer almost every brand skips. Processing NMN burns through methyl groups. Over time that runs your methylation down, and hands you the fatigue, brain fog and low mood you started supplementing to fix in the first place.
TMG (Trimethylglycine)500mg
Your primary methyl donor. Professor David Sinclair has openly advocated taking TMG alongside NMN.
Methylcobalamin (B12)1000mcg
A methylation cofactor that works alongside TMG to keep the cycle running.
The solution
So we built the one supplement we couldn't buy: NAD Surge.
Three gaps.
One pathway fed. CD38 draining what you build. Methylation quietly running down.
Once we saw them, the fix was obvious... it just didn't exist on any shelf.
So the LongevityBox team formulated it ourselves.
One daily serving that builds NAD+ across all three routes, protects it from CD38, and sustains the methylation behind it.
Developed in the lab. Dosed to the published research. Independently tested, batch by batch.
Formulated in-house to the published researchEvery dose weighed and declared, never hidden in a blendIndependently tested, batch by batch
What's inside
Seven ingredients. Every dose published. Every choice backed by research.
No proprietary blends. Nothing hidden. Here's exactly what's in every serving, why it's there, and the research behind each dose. Every milligram printed, every one colour-coded to its layer.
7
active ingredients
3
layers in one serving
1
daily dose, 3 capsules
Build
NMN 300mg
A direct NAD+ precursor, and one of the most studied longevity compounds in humans. Improved walking speed and grip strength in over-65s (Igarashi et al., 2022, npj Aging). Shown safe up to 900mg/day.
Build
NR (Nicotinamide Riboside) 250mg
A second precursor that takes a different route to NMN. Human trials have shown NR raises NAD+ levels (Martens et al., 2018, Nature Communications).
Build
Niacin (Nicotinic Acid) 150mg
A third precursor opening a separate route to NAD+. The oldest and most studied of the three, here so all three routes are fed at once.
Protect
Quercetin 250mg
A flavonoid with a documented ability to slow CD38 that also supports immune function and acts as an antioxidant. Softens the mild niacin flush.
Protect
Apigenin 100mg
A CD38 inhibitor. In lab studies, apigenin raised NAD+ by roughly 50% by suppressing CD38 (Escande et al., 2013, Diabetes). Full dose declared.
Sustain
TMG (Trimethylglycine) 500mg
Your primary methyl donor. Replaces the methyl groups used up when your body processes NMN, heading off methylation debt.
Sustain
Methylcobalamin (B12) 1000mcg
A methylation cofactor that works alongside TMG to keep your methylation running smoothly.
1,551mg active per serving
Three capsules a day, with food. No fillers, no binders, no proprietary blends. Vegan, and free from gluten, dairy, soy, egg and nuts.
Nothing to hide on the label
We declare every ingredient and every dose, including the CD38 inhibitors and methylation support most brands bury in a blend or leave out entirely. Every batch is independently tested and backed by our 700-day purity guarantee. What's on the label is what's in the capsule.
Side by side
How NAD Surge compares
Feature
NAD Surge
Nuchido TIME+
DoNotAge NMN
DIY Stack
Monthly price
£39.99
£55–65
£40–50
£60–90
NAD+ precursors
3 (NMN + NR + Niacin)
1 (Nicotinamide)
1 (NMN)
Varies
CD38 inhibitors
2 (Quercetin + Apigenin)
Undisclosed blend
None
If you remember
Methylation support
Yes (TMG + B12)
None
None
If you remember
Doses declared
Every ingredient
Hidden in blend
Single ingredient
Varies
Independently tested
✓
Not stated
✓
Varies
Purity guarantee
700 days
None
None
None
More complete, more transparent, and cheaper than its closest rivals. Not because we cut corners, but because we built one focused formula and sell it to you direct.
Rated by real customers
Loved across our NAD+ range
4.9
TrustScore
Based on 19 verified NAD Surge reviews
Verified purchase
Finally broke my plateau
"I was taking a premium NMN for a year but hit a plateau. Switching to the NAD Surge system changed the game."
James F.✓ Verified
Verified purchase
Energy and focus, noticeably better
"The difference in my energy and focus has been remarkable. I've tried multiple supplements over the years and LongevityBox is the one I keep coming back to."
Verified customer✓ Verified
Verified purchase
Post-menopause game-changer
"I'm 62 and in post-menopause and have really struggled with tiredness, energy and cognitive decline, but wow, this is brilliant."
Verified customer✓ Verified
Verified purchase
The one I've stuck with
"I tried lots of different NMN, starting with the most well-known companies. I've chosen this one to stick to."
Verified customer✓ Verified
Reviews are from LongevityBox customers across our NAD+ and longevity range, built over more than 300,000 customers in five years. NAD Surge is now live, and product-specific reviews are being added as they come in.
Part of a real morning
A daily habit, not a quick fix
Three capsules with breakfast. That's the whole routine. The system works underneath while you get on with your day.
Steadier morningsNo more plateauSharper at 54Did the research
What to expect
What the first few months can look like
Everyone responds differently, and real change here is gradual, not overnight. But here's the pattern most people describe.
You're not taking a stimulant. You're rebuilding the system underneath.
Weeks 2–4
Steadier energy and fewer afternoon dips. The system is taking hold, not delivering a short-term hit.
Weeks 4–8
The mental fog starts to lift and focus holds for longer. Harder to dismiss as placebo.
2–3 months
The slower, compounding changes: easier recovery, deeper sleep, a higher baseline rather than a quick lift.
6 months+
A shifted baseline. Steadier energy that doesn't need managing, and a NAD+ protocol that's complete, not leaking.
☀️ Summer launch offer
Choose your NAD+ system
One daily serving. Everything your NAD+ actually needs. Launch price £39.99, down from an RRP of £49.99. Most people subscribe, so they never run out and lock in the lowest price.
Most Popular
Monthly Subscription
£33.99/mo
£39.99/mo
£1.13 / day15% off, forever
Save 15% forever, the lowest cost per serving of any option
60-Day Money-Back Guarantee + 700-Day Purity Guarantee on every order. No contracts, no dark patterns.
Our promise
Try it properly, risk-free for 60 days.
Track how you feel. Keep what works. If you don't notice a meaningful difference within 60 days, or you simply change your mind, send it back for a full refund. Even if the pouch is opened. On top of that, every batch is independently tested and carries our 700-day purity guarantee.
You either feel the difference, or you pay nothing.
Independently testedfor purity & potency
700-day purityquality guarantee
Free UK shippingon orders over £50
Common questions
Frequently asked questions
How long until I feel something?
Most people notice better energy within two to four weeks. Clearer thinking tends to follow around weeks four to eight. Visible changes like recovery usually show up over two to three months. Everyone is different, but that timeline lines up with the published research.
Should I take NMN or NR?
Both, and neither on its own. NMN and NR take different routes to NAD+, so most people get more from the two together than from either alone. That's the whole point of a system: NAD Surge gives you both, plus niacin, so you're never stuck picking a side.
Why does feeding all three pathways matter?
Your body makes NAD+ through three separate routes, and NMN only feeds one. NR takes a second and niacin a third. Rely on a single route and once it's saturated you hit a ceiling no matter how much you take. NAD Surge feeds all three at once.
I've tried other NAD+ supplements and felt nothing. Why would this be different?
Most give you one precursor through one pathway. If that pathway is already capped, you hit a ceiling no matter how long you take it. On top of that, CD38 is breaking your NAD+ down as fast as you make it, and processing NMN burns through your methyl groups. NAD Surge tackles all three bottlenecks at once. A genuinely different approach, not just a different brand.
Is NMN safe and legal in the UK?
Yes. NMN has received Novel Food approval, and NR is fully authorised for sale. NMN has been used in several published human trials with no serious side effects reported, and NAD Surge uses 300mg, well within the range shown to be safe. As with any supplement, check with your GP before you start, especially if you take prescription medication.
What if I'm already taking NMN from another brand?
Switch. NAD Surge already gives you 300mg of NMN plus two more precursors, the CD38 inhibitors and the methylation support. Taking it on top of a standalone NMN would just double up on NMN for no reason.
How is this better than buying NMN and TMG separately?
You could build a similar stack yourself across four to six bottles. Most people who try end up paying £60–90 a month, juggling uneven quality between brands, and still missing the CD38 protection layer. NAD Surge brings it all into one tested formula at £39.99.
Do I need to take it forever?
NAD+ keeps falling as you age, so if you stop, your levels drift back to baseline. Most people treat NAD Surge as a daily habit, much like Omega 3 or Vitamin D. The subscription is built for that, though you can cancel anytime with no contracts.
How do I take it, and are there allergens?
Three capsules daily, ideally with a meal containing some fat to help quercetin absorption. It's vegan and free from gluten, dairy, soy, egg and nuts, with no fillers or binders.
Stay as you are
Keep feeding one pathway
✕Your NAD+ keeps sliding, month after month
✕The fog and afternoon crashes creep back in
✕Another plateau. More money, still no answer
Step up
Switch to the complete system
✓NAD+ built, protected and sustained, all at once
✓Steadier energy and focus that holds all day
✓A higher baseline you keep, month after month
Your NAD+ system starts here
Keep feeding one pathway. Or step up to the complete system.
Your NAD+ falls a little more every month, and CD38 keeps draining what's left. Waiting isn't neutral. It's lost ground you don't get back. Three precursors. Two CD38 inhibitors. Full methylation support. One serving a day, from under £1, backed by a 60-day money-back guarantee.
